【Introduction】： Frontotemporal dementia (FTD) is characterized by phenotypic and genetic heterogeneities. However, reports on the large Chinese FTD cohort are lacking. 【Meth...

【Aims】： Apply established cerebrospinal fluid (CSF) and serum biomarkers and novel combined indicators based on the amyloid/tau/neurodegeneration (ATN) framework to improve diagnostic and pr...

【Background】： Previous studies have demonstrated that early intervention was the best plan to inhibit the progression of Alzheimer’s disease (AD), which relied on the discovery of early diagnostic bi...

【Highlights】： ?P-tau217 correlates with brain atrophy and cognitive impairment in AD patients ?Antibody against p-tau217 attenuates pathology and neuronal loss in tauopathic mice ?P-tau217 antibody...

【PUBLIC SUMMARY】: - In-depth proteomics workflow for profiling paired cerebrospinal fluid (CSF) and serum proteomes. - Independent multicenter set combined with multiple methods for...

【Background】Mutations in colony-stimulating factor 1 receptor (CSF1R) are known to cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which has been recen...

【Background】: Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) were two major motor neuron diseases with similar symptoms and poor outcomes. This study aimed to ident...

【Abstract】 Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s and cardi...